5 or 1'-Hydroxy-2-alkyl-7,8-cyclopentano[h]-1,2,3,4-tetrahydrois

Details 5 or 1'-Hydroxy-2-alkyl-7,8-cyclopentano[h]-1,2,3,4-tetrahydrois 5 or 1'-Hydroxy-2-alkyl-7,8-cyclopentano[h]-1,2,3,4-tetrahydrois

1974-03-28

1976-03-30

Gallagher, Richard J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260286R, 260286Q, 260287D, 260289C, 260289K, 260289D, 424258, C07D21700

Patent

active

039474542

ABSTRACT:
5 OR 1'-Hydroxy-2-alkyl-7,8-cyclopentano[h]-1,2,3,4-tetrahydroisoquinolines and esters of the formulas ##SPC1##
Wherein R is a lower alkyl having 1 to 6 carbon atoms, R.sub.1 is hydrogen, a lower alkyl group, an alkanoyl, benzoyl or aralkanoyl group, R.sub.2 is a lower alkyl group and R.sub.3 is hydrogen, benzoyl, an alkanoyl group or an aralkanoyl group, and acid addition salts and quaternary ammonium salts thereof. The compounds are useful in pharmaceutical compositions for lowering blood pressure in animals.
Wherein R is a lower alkyl having 1 to 6 carbon atoms, R.sub.1 is hydrogen, a lower alkyl group, an alkaoyl, benzoyl or aralkanoyl group, R.sub.2 is a lower alkyl group and R.sub.3 is hydrogen, benzoyl, an alkanoyl group or an aralkanoyl group, and acid addition salts and quaternary ammonium salts thereof. The compounds are useful in pharmaceutical compositions for lowering blood pressure in animals.

REFERENCES:
morrison et al., "Organic Chemistry", 1966, pp. 314-315.
Marchant, "J. Chem. Soc.", 1956, p. 327ff.
March, "Advanced Organic Chemistry", 1968, p. 349.
Morrison and Boyd, "Organic Chemistry", 1966, p. 631.
Burger, "Medicinal Chemistry", pp. 42, 497.

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