5-nitrobenzo[de]isoquinoline-1,3-diones their preparation and th

Details 5-nitrobenzo[de]isoquinoline-1,3-diones their preparation and th 5-nitrobenzo[de]isoquinoline-1,3-diones their preparation and th

1990-06-04

1996-09-03

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

546100, C07D41306, C07D22114, A61K 3144, A61K 31535

Patent

active

055525440

ABSTRACT:
An antitumor 5-nitrobenzo[de]isoquinoline-1,3-dione of the formula I ##STR1## where n is 1 or 2, R.sup.1 and R.sup.2 are identical or different and are each hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -hydroxyalkyl, pyrrolidinyl, morpholino, piperidinyl or piperacinyl and R.sup.3 and R.sup.4 are identical or different and are each hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -acyl, C.sub.2 --C.sub.7 -alkoxycarbonyl, ureyl, aminocarbonyl or C.sub.2 -C.sub.7 -alkylaminocarbonyl, and its salts with physiologically tolerated acids, are described.

REFERENCES:
patent: 4204063 (1980-05-01), Brana
patent: 4614820 (1986-09-01), Zee-Ching
patent: 4782064 (1988-11-01), Wright
Paull et al. Arzneim, Forsch./Drug Res. 34 (II) (1984), 1243-1246.

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