5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethyl

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai

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514912, A61K 31275

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active

056773358

ABSTRACT:
The use of 5-methyl-isoxazole-4-carboxylic acid anilides and 2-hydroxyethylidene-cyano acetic acid anilides for treating ocular diseases with immune etiology is disclosed.

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Nussenblatt et al., "Cyclosporine: Imunology Pharmacology and Therapuetic Uses," Survey of Ophthalmology, vol. 31(3), pp. 159-169, (1986).
BenEzra et al., "Cyclosporine Eyedrops for the Treatment of Severe Vernal Keratoconjunctivitis," American Journal of Ophthalmology, vol. 101, pp. 278-282, (1986).
Bartlett, et al., "Development of Autoimmunity in MRL/lpr Mice and the Effects of Drugs on this Murine Disease," Scand. J. Rheumatology, Suppl. 75, pp. 290-299, (1988).
Berkow, et al., "Allergic Conjunctivitis,"and Vernal Keratoconjunctivitis, The Merck Manual, pp. 312 and 2222-2223, (1987).
Bartlett, "Immunopharmacological Profile of HWA 486, a Novel Isoxazol Derivative," Int. J. Immunopharmacol., vol. 8, No. 2, pp. 199-204, (1986).

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