5-Methyl-isoxazole-4-carboxylic acid anilides

Details 5-Methyl-isoxazole-4-carboxylic acid anilides 5-Methyl-isoxazole-4-carboxylic acid anilides

1976-06-03

1978-05-02

Rush, Raymond V.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

260307H, 260562K, C07D26118, A61K 3142

Patent

active

040875350

ABSTRACT:
A 5-methyl-isoxazole-4-carboxylic acid anilide is prepared by heating an acetoacetic acid anilide with an orthoformic acid ester and a carboxylic acid anhydride, isolating the resulting 2-alkoxymethylene-acetoacetic acid anilide and then treating it with hydroxylamine in an organic solvent. The compounds of the invention have anti-inflammatory and analgetic activity.

REFERENCES:
patent: 2126329 (1938-08-01), Hoffer
patent: 2288863 (1942-07-01), Wenner
Dains et al., J. Am. Chem. Soc. 35, pp. 959, 968 (1913).
Ajello et al., C.A. 81, 120589t (1974).

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