5-methyl-5-deaza analogues of methotrexate and N.sup.10 -ethylam

Details 5-methyl-5-deaza analogues of methotrexate and N.sup.10 -ethylam 5-methyl-5-deaza analogues of methotrexate and N.sup.10 -ethylam

1986-04-28

1988-02-16

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

546287, C07D47104, A61K 31505

Patent

active

047256877

ABSTRACT:
It is disclosed that 5-methyl-5-deazamethotrexate and 5-methyl-5-deaza-10-ethylaminopterin are more than 10 times as potent as 5-deazamethotrexate in the L1210 cell growth inhibition test.

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Piper et al., J. Med. Chem., 1986, 29, 1080-1087.
Griusky et al., J. Med. Chem., 1980, 23, 327.
Edward C. Taylor et al., J. Org. Chem., vol. 48, No. 25, pp. 4852-4860 (1983).
"Synthesis of Fused Pyrimidines as Folate Antagonists", (1974) Elslager et al, Lect. Heterocycl. Chem., vol. II, pp. S97-S133.
Monatsch. Chem., Schmidt et al, vol. 108, pp. 895-900 (1977).

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