5-Methyl-1-(trifluoromethyl)-2-naphthalenol, process for its pre

Details 5-Methyl-1-(trifluoromethyl)-2-naphthalenol, process for its pre 5-Methyl-1-(trifluoromethyl)-2-naphthalenol, process for its pre

1983-06-22

1985-02-12

Helfin, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568737, C07C 3914, C07C 3706, C07C 4320

Patent

active

044993102

ABSTRACT:
A process and intermediates for preparing 6-(lower alkoxy)-5-(trifluoromethyl)-1-naphthalenecarboxylic acid derivatives are disclosed. The derivatives are useful for preparing aldose reductase inhibitors. With reference to the process, 1,1,1-trifluoro-5-(2-methylphenyl)-2,3-pentadione 3-oxime is cyclized to give a key intermediate 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone oxime; and 3,4-dihydro-1-hydroxy-5-methyl-1-(trifluoromethyl)-2(1H)-naphthalenone is aromatized to 5-methyl-1-(trifluoromethyl)-2-naphthalenol with a dehydrating agent.

REFERENCES:
patent: 4408077 (1983-10-01), Sestanj et al.
Harvey et al., Jour. Chem. Soc., (1930), 423-431.

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