5-membered annelated heterocyclic pyrimidines as kinase...

Details 5-membered annelated heterocyclic pyrimidines as kinase... 5-membered annelated heterocyclic pyrimidines as kinase...

2011-05-24

2011-05-24

Moore, Susanna (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S265100, C514S263220, C514S252160, C544S262000, C544S280000, C544S277000

Reexamination Certificate

active

07947695

ABSTRACT:
This invention comprises the novel compounds of formula (I)wherein R1, R2, R3, R4, R5, R6, Q1, Q2, X1, X2, Y and Z have defined meanings, having cell cycle kinase inhibiting enzymatic activity, their preparation, compositions containing them and their use as a medicine.

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Strecker et. al. (Expert Opin. Emerging Drugs, 2008, pp. 573-591).
Fischer, P.M., et al., “CDK inhibitors in clinical development for the treatment of cancer”, Expert Opin. Investig. Drugs, vol. 12, No. 6 (2003), pp. 955-970.
McLaughlin, F., et al., “The cell cycle, chromatin and cancer: mechanism-based therapeutics come of age”, Drug Discovery Today, vol. 8, No. 17 (2003), pp. 793-802.
International Search Report PCT/EP2006/050097, mailed Apr. 3, 2006.

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