5-lipoxygenase inhibitors

Details 5-lipoxygenase inhibitors 5-lipoxygenase inhibitors

1988-10-14

1991-07-30

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514570, 514712, A61K 31235

Patent

active

050361058

ABSTRACT:
This invention encompasses compounds and methods for inhibiting lipoxygenase and includes a pharmaceutical composition comprising a pharmaceutical carrier and an effective lipoxygenase inhibiting amount of a compound of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different members of the group consisting of tert-alkyl of 4 to 10 carbon atoms; and R.sub.3 is

REFERENCES:
patent: 4012523 (1977-03-01), Wagner
patent: 4067998 (1978-01-01), Wagner
patent: 4108831 (1978-08-01), Cottman
patent: 4198425 (1980-04-01), Mitsui et al.
patent: 4262013 (1981-04-01), Mitsui et al.
patent: 4857558 (1989-08-01), Mueller
Wagner, E. R., et al., "Hypolipidemic Arylthioalkanoic Acids", J. Med. Chem., 1977, vol. 20, No. 8, 1007-1013.
Foegh et al. Improved Rat Cardiac Allograft Survival with Non-Steroidal Pharm Agents., Transplant Proc., 19,1297-1300 (Feb. 1987).
Foegh, et al., Presentation at NIH Workshop, Potential Therapeutic Use of Inhibitors of Leukotriene . . . , Jun. 23, 1986 (trip report attached).

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