5-lipoxygenase-activating protein II

Details 5-lipoxygenase-activating protein II 5-lipoxygenase-activating protein II

1997-04-22

2000-11-14

Achutamurthy, Ponnathapu

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 536 235, 435 691, 435325, 435 71, A61K 3816, C07K 100, C07H 2104, C12P 2106

Patent

active

061470503

ABSTRACT:
Disclosed is a human FLAP II polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Further, antagonists against such polypeptide are disclosed. Such antagonists may be used for therapeutic proposes, for example, for treating inflamation, bronchial asthma and may also be used as gastric cytoprotective agents and to treat human glomerulonephritis. Diagnostic assays for identifying mutations in nucleic acid sequences encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.

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Vickers, P.J. et al., Mol. Pharmocol., 42:94-102 (1992).
Vickers, P.J. et al., Mol. Pharmocol., 42:1014-9 (1992).
Bennet, C.F. Et al., Biochem. J., 289 (pt. 1):33-9 (1993).
Rifai, A. Et al., Kidney Int. Suppl., 39:595-9 (1993).
Vickers, P.J. Et al., J. Lipid Mediat., 6:31-42 (1993).

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