Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-06-22
1997-12-09
Hendricks, Keith D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
536 235, 530350, 4352401, 4352402, 4352404, 4352523, 514 2, A61K 3816, C12N 1512
Patent
active
056960760
ABSTRACT:
Disclosed is a human FLAP II polypeptide and DNA (RNA) encoding such polypeptide. Also provided is a procedure for producing such polypeptide by recombinant techniques. Further, antagonist/inhibitors against such polypeptide are disclosed. Such antagonist/inhibitors may be used for therapeutic purposes, for example, for treating inflammation, bronchial asthma and may also be used as gastric cytoprotective agents and to treat human glomerulonephritis.
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Jakobsson, P.J., et al., On the Expression and Regulation of 5-lipoxygenase in human lymphocytes, PNAS USA, 89:2521-5 (1992).
Vickers, P.J., et al., Identification of amino acid residues of 5-lipoxygenase-activating protein essential for the binding of leukotriene biosynthesis inhibitors, Mol. Pharmocol., 42:94-102 (1992).
Vickers, P.J. et al., Cross-species Comparison of 5-lipoxygenase- activating protein, Mol. Pharmocol, 42:1014-9 (1992).
Bennet, C.F., et al., Regulation of 5-lipoxygenase and 5-lipoxygenase-activating protein expression in HL60 cells, Biochem. J., 289 (pt. 1):33-9 (1993).
Rifai, A., et al., Expression of 5-lipoxygenase and 5-lipoxygenase activation protein in glomerulonephritis, Kidney Int. Suppl., 39:595-9 (1993).
Vickers, P.J. et al., Amino Acid Residues of 5-lipoxygenase-activating protein critical for the binding of leukotriene biosynthesis inhibitors, J. Lipid Mediat., 6:31-42 (1993).
Fleischmann Robert D.
Gentz Reiner L.
Hendricks Keith D.
Human Genome Sciences Inc.
Olstein Elliot M.
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