5-lipoxygenase-activating protein (FLAP) inhibitors

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate



Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of 5-lipoxygenase-activating protein (FLAP). Also described herein are methods of using such FLAP modulators, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions or diseases.

patent: 5081138 (1992-01-01), Gillard et al.
patent: 2004/0198800 (2004-10-01), Allan et al.
patent: 1749829 (2006-03-01), None
Miller et al., “Identification and isolation of a membrane protein necessary for leukotrine production,” Nature 343:278-281 (1990) Abstract only.
PCT/US06/39421 Search Report dated Jan. 18, 2008.


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