Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1988-10-27
1990-01-23
Hazel, Blondel
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C07H 19067
Patent
active
048959375
ABSTRACT:
The nuceoside 1-(2-Deoxy-.beta.-D-ribofuranosyl)-5-(iodo)-2-pyrimidinone possesses a high level of antiviral activity and a low level of toxicity to the host cell making it an especially effective therapeutic agent for HSV-2.
REFERENCES:
Chemical Abstracts, vol. 93, Abstract No. 8845430, 1980.
Oftebro, R. et al, Biochemical Pharmacology, vol. 21, pp. 2451-2456, Pergamon Press, 1972.
Oyen, T. B. et al., Biochim. Biophys. Acta, 182, pp. 567-569, 1969.
Torrence, P. F., et al., Frontiers in Bioorganic Chemistry and Molecular Biology, pp. 59-858, Elsevier/North-Holland Biomedical Press.
McCormack, J. J., et al., Biochemical Pharmacology, vol., 29, pp. 830-832, 1980.
Goodman & Gilman, The Pharmacological Basis of Therapeutics, (1980) pp. 1240-1241.
Prusoff, W. H., et al., Antiviral Research, 4, pp. 303-315, Elsevier, 1984.
Bardos Thomas J.
Cheng Yung-Chi
Efange Simon M. N.
Schroeder Alan C.
Dunn Michael L.
Ellis Howard M.
Hazel Blondel
The Research Foundation of State University of New York
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