5-Hydroxyl-1,2,3-triazole-4-carboxamide nucleoside

Details 5-Hydroxyl-1,2,3-triazole-4-carboxamide nucleoside 5-Hydroxyl-1,2,3-triazole-4-carboxamide nucleoside

1973-03-19

1976-04-06

Brown, Johnnie R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260308A, 424180, C07H 1904

Patent

active

039488853

ABSTRACT:
A 5-hydroxy-1,2,3-triazole-4-carboxamide nucleoside, related to the C-nucleoside pyrazomycin, is facilely synthesized by condensation of acyl-blocked ribofuranose with trimethylsilylated 5-hydroxy-1,2,3-triazole-4-carboxamide or, alternatively, by cycloaddition of suitably blocked .beta.-D-ribofuranosyl azide and the anion of ethyl malonamate, and demonstrated to exhibit antiviral properties. The triazole precursor of the former route, as well as certain of its novel salts, are also disclosed as potential antiviral agents.

REFERENCES:
patent: 3470196 (1969-09-01), Harvey
patent: 3598807 (1971-08-01), Nakayama et al.
Alonso, G. et al., "J. Hetero. Chem.," Vol. 7, 1970, pp. 1269-1272.
Witkowski, J. T. et al., "J. Org. Chem.," Vol. 35, No. 8, 1970, pp. 2635-2639.
Tipson, "Advances in Carbohydrate Chemistry and Biochemistry," Vol. 25, Academic Press, New York, N.Y., 1970, pp. 387-388.

Affiliated with

Also associated with

Rating

5-Hydroxyl-1,2,3-triazole-4-carboxamide nucleoside does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-Hydroxyl-1,2,3-triazole-4-carboxamide nucleoside, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-Hydroxyl-1,2,3-triazole-4-carboxamide nucleoside will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1575775