5-Hydroxy-.alpha.-(substituted aminomethyl)-m-xylene-.alpha.,.al

Details 5-Hydroxy-.alpha.-(substituted aminomethyl)-m-xylene-.alpha.,.al 5-Hydroxy-.alpha.-(substituted aminomethyl)-m-xylene-.alpha.,.al

1976-04-07

1977-04-19

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260471R, 26050117, 26050118, 260519, 424309, 424316, 424330, C07C 9122

Patent

active

040188256

ABSTRACT:
Compounds of the formula: ##STR1## are disclosed, wherein R.sub.1 and R.sub.2 are hydrogen; or where R.sub.1 is methyl, R.sub.2 is hydrogen, phenyl, or phenyl substituted in the para-position by hydroxy, alkoxy, chloro, phenyl or alkyl having 1-6 carbon atoms. The compounds of this invention are useful in the treatment of bronchial asthma. These compounds exhibit unique biological properties in that they provide the desired bronchial dilation effect without accompanying cardiac stimulation.

REFERENCES:
patent: 3631108 (1971-12-01), Brandstrom et al.
patent: 3644353 (1972-02-01), Luntz et al.
Bergman et al., "Experientia," vol. 25, pp. 899-901, (1969).
Bronchodilators, "Manufacturing Chemist and Aerosol News," vol. 40, p. 43, (1969).
Hartley et al., "Nature," vol. 219, pp. 861-863, (1968).

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