Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-04-14
2000-08-22
Jarvis, William R. A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 31415
Patent
active
061073245
ABSTRACT:
Disclosed herein is a new class of pyrazole compounds which act at the 5HT.sub.2A receptors.
REFERENCES:
patent: 4985352 (1991-01-01), Julius et al.
patent: 5661024 (1997-08-01), Kao et al.
Barluenga, J. et al., "A New and Specific Method for the Monomethylation of Primary Amines," J. Chem. Soc. Chem. Commun., 1984, 20, 1334-1335.
Batey, R.A. et al., "An Efficient New Protocol for the Formation of Unsymmetrical Tri-and Tetrasubstituted Ureas," Tetra. Lett., 1998, 39, 6267-6270.
Bernatowicz, M. et al., "A Comparison of Acid Labile Linkage Agents for the Synthesis of Peptide C-Terminal Amides," Tetra. Lett., 1989, 30(35), 4645-4648.
Carter, H.E. et al., "Carbobenzoxy Chloride and Derivatives," Org. Syn. Coll., 1955, vol. 3, 167-169.
Casey, C. et al., "Constitutively Active Mutant 5HT.sub.2A Serotonin Receptors: Inverse Agonist Activity of Classical 5HT.sub.2A Antogonists," Society for Nueroscience Abstracts, 1996, 22(3), Abstract No. 699.10.
Gutsche, C.D. et al., "2-Phenylcycloheptanone," Org. Syn. Coll., 1963, vol. 4, 780-783.
Herrick-Davis, K. et al., "Activating Mutations of the Serotonin 5-HT.sub.2C Receptor," J. Neurochem., 1997, 69(3), 1138-1144.
Herrick-Davis, K. et al., "Constitutively Active 5HT2C Serotonin Receptor Created by Site-Directed Mutagenesis," Society for Nueroscience Abstracts, 1996, 22(3), Abstract No. 669.18.
Konig, W. et al., "A New Method for Synthesis of Peptides: Activation of the Carboxyl Group with Dicyclohexylcarbodiimide using 1-Hydroxybenzotriazoles as Additives," Chem. Ber., 1970, 103, 788-798 (English abstract included).
Marchini, P. et al., "Sodium Borohydride-Carboxylic Acid Systems. Useful Reagents for the Alkylation of Amines," J. Org. Chem., 1975, 40(23), 3453-3456.
Sahgal, A. (ed.), "Practical behavioral neuroscience: problems, pitfalls and suggestions," in Behavioral Neuroscience: A Practical Approach, IRL Press, New York, 1993, vol. 1, 1-8.
Sheehan, J.C. et al., "1-Ethyl-3-(3-Dimethylamiono)Propylcarbodiimide Hydrochloride and Methiodide," Org. Syn. Coll., 1973, vol. 5, 555-558.
Soresnon et al., "Characterization of the 5-HT.sub.2 Receptor Antagonist MDL 100907 as a Putative Atypical Antipsychotic: Behavioral, Electrophysiological and Neurochemical Studies," J. Pharacol. Exp. Ther., 1993, 266(2), 684-691.
White, E., "Deamination of Amines. 2-Phenylethyl Benzoate Via the Nitrosoamide Decomposition," Org. Syn. Coll., 1973, vol. 5, 336-339.
Behan Dominic P.
Chalmers Derek T.
Foster Richard J.
Glen Robert C.
Lawless Michael S.
Arena Pharmaceuticals Inc.
Burgoon, Jr. Richard P.
Jarvis William R. A.
Tripos, Inc.
LandOfFree
5-HT2A receptor inverse agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 5-HT2A receptor inverse agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-HT2A receptor inverse agonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-581527