5-HT2 receptor ligands

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

540547, A61K 3155, C07D40304, C07D41704, C07D41304

Patent

active

058246762

ABSTRACT:
Described herein are 5-HT2 receptor-selective compounds of Formula I: ##STR1## wherein: A and B are independently selected, optionally substituted, saturated or unsaturated 5- or 6-membered, homo- or heterocyclic rings;

REFERENCES:
patent: 3539573 (1970-11-01), Schmutz
patent: 3546226 (1970-12-01), Schmutz
patent: 3751415 (1973-08-01), Schmutz
patent: 3758479 (1973-09-01), Schmutz
patent: 3908010 (1975-09-01), Schmutz
patent: 3983234 (1976-09-01), Sayers
patent: 4096261 (1978-06-01), Horrom
patent: 4115574 (1978-09-01), Chakrabarti
patent: 4216148 (1980-08-01), Hofman
patent: 4931447 (1990-06-01), Foreman
patent: 5229382 (1993-07-01), Chakrabarti
patent: 5354747 (1994-10-01), Hansen
patent: 5602121 (1997-02-01), Fu
Gianai et al Synthesis, 1985, p. 550 "A new facile synthesis of
Harris et al J Med Chem, 1982, 25:855 "Affinity of binding sites in rat brain".
Klunder et al J Med Chem, 1992, 35:1887 "Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. tricyclic pyridobenzoxazepinones and dibenzoxazepinones".
de Paulis et al J Med Chem, 1981, 24(9):1021 "Synthesis of clozapine analogues and their affinity for clozapine and spiroperidol binding sites in rat brain".
Sindelar et al Coll. Czechoslov. Chem. Commun., 1977, 42:2231 Noncataleptic potential neuroleptics: 2-nitro and 2-hydroxy derivatives of
The Merck Manual of Diagnosis and Thrapy, 15th ed. (1987), Berkow, M.D. editor, pp. 2486-2487.
Chakrabarti et al., J. Med Chem., "Effects of Conformationally Restricted 4-Piperazinyl-10H-thienobenzodiazepine Neuroleptics on Central Dopaminergic and Cholinergic Systems", 25, 1133-1140 (1982).
Sindelar et al., Coll. Czechoslov. Chem. Commun., "Neuroleptics of the Substances: Piperazine-Alkylated Homologues of Octoclothepin and of Perathiepin", 41, 910-922 (1976).
Steiner et al., J. Med. Chem., "Tricyclic Epines. Novel (E)-and Variation of the Basic Side Chain", 29, 1877-1888 (1986).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

5-HT2 receptor ligands does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-HT2 receptor ligands, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-HT2 receptor ligands will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-244555

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.