5-HT.sub.1F mediated inhibition of neurogenic meningeal extravas

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514250, 514411, 514415, 514657, A61K 31445, A61K 31405, A61K 3140, A61K 3113

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active

056985711

ABSTRACT:
The present invention provides a method for the treatment of migraine with compounds or compositions that are selective agonists of 5-HT.sub.1F receptors relative to other serotonin receptors that produce unwanted effects like vasoconstriction. The neurogenic meningeal extravasation that leads to the pain of migraine is inhibited.

REFERENCES:
Lee et al., American Journal of Physiology, 266 (3 Pt. 2) H1000-6, 1994.
Moskowitz, M.A., TiPS, 13 (8), 307-311 (1972).
Moskowitz, M.A., and Macfarlane, Robert, Cerebrovascular and Brain Metabolism Reciews, 5, 159-177 (1993).
Fozard, J.R., "Migraine: A Spectrum of Ideas", Sandler, M., and Collins, G.M. (eds.), Oxford University Press: New York (1990).
Moskowitz, M.A., Neurology, 43 (Suppl 3), 16-20 (1993).
Silberstein, S.D., Headache, 34, 408-417 (1994).
Adham, et al., Prac. Natl. Acad. Sci., 90, 408-412 (1993).

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