5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof a

Details 5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof a 5-Heteryl-1,6-naphthyridin-2(1H)-ones, cardiotonic use thereof a

1985-01-14

1986-01-28

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514345, 546122, 546123, 546283, 546284, A61K 31435, C07D47104, C07D21324

Patent

active

045671869

ABSTRACT:
3-Z-5-Q-1,6-naphthyridin-2(1H)-ones (I) or salts thereof, where Z is hydrogen or cyano, and Q is 2(or 3)-furanyl, 2(or 3)-thienyl, 4(or 3)-pyridinyl or 4(or 3)-pyridinyl having one or two methyl substituents, are useful as cardiotonic agents and corresponding compounds where Z is carboxy are useful as intermediates. Also shown as intermediates are 5-(Q-CO)-6-[2-(di-lower-alkylamino)ethenyl]-2(1H)-pyridinones (II) or salts thereof, where Q is defined as above. Processes for preparing said compounds (I and II) are shown.

REFERENCES:
patent: 4412077 (1983-10-01), Lesher et al.
patent: 4415580 (1983-11-01), Lesher et al.
Hawes and Gorecki, J. Med. Chem. 16, 849-853 (1973).
U.S. patent application Ser. No. 630,810, filed Jul. 13, 1984 (Lesher and Singh).

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