5-heterocyclyl pyrazolo[4,3-d]pyrimidin-7-ones for the treatment

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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544118, 544262, A61K 31519, C07D48704

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active

060778415

ABSTRACT:
The invention is directed to novel substituted 5-heterocyclyl pyrazolopyrimidinones and derivatives thereof, their synthesis and their use in treating sexual dysfunction in mammals, especially male erectile dysfunction. Pharmaceutical compositions containing the compounds and methods of using them to treat sexual dysfunction are also described.

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patent: 5346901 (1994-09-01), Bell et al.
J. Org. Chem. vol. 40 No. 19; Tam Huynh-Dinh, annie Kolb, Catherine Gouyette and Jean Igolen; Synthesis of C Nucleosides.X1 Structural Analogs of Formycin B; pp. 2825-2830 (1975).
J. Med. Chem; Harriet W. Hamilton Daniel F. Ortwine, Donald F. Worth, and James A. Bristol; Synthesis and Structure--Activity Relatioships of Pyrazolo[4,3-d]pyrimidin-7-One as Adenosine Receptor Antagonists; vol. 30; pp. 91-96 (1987).
J. Med. Chem.; C. Subramanyam et al; 6-(4-Pyridinyl)-H-1,2,3-Triazolo{4,5-D]-Pyrimidin-4 (5h)--One: A Structurally Novel Competitive AMPA Receptor Antagonist; vol. 38; pp. 587-589 (1995).

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