5-hetero-or aryl-substituted-imidazo(2,1-a)isoquinolines and the

Details 5-hetero-or aryl-substituted-imidazo(2,1-a)isoquinolines and the 5-hetero-or aryl-substituted-imidazo(2,1-a)isoquinolines and the

1989-01-27

1990-03-20

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142282, 5142332, 514212, 514255, 544 60, 544126, 544361, 540599, 546 14, 546 84, A61K 31435, A61K 31495, C07D41702, C07D47104

Patent

active

049102060

ABSTRACT:
The invention discloses certain 5-hetero or aryl-substituted-imidazo[2,1-a]isoquinolines useful as platelet activating factor (PAF) receptor antagonists, pharmaceutical compositions containing said compounds as an active ingredient thereof and a method of using such compositions for inhibiting PAF-mediated bronchoconstriction and extravassation and PAF-mediated, endotoxin-induced lung injury, and for controlling hyperreactive airways induced by PAF or allergin. In addition, the invention discloses the use of a select group of said compounds as anti-tumor agents.

REFERENCES:
patent: 4101553 (1978-07-01), Houlihan

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