5-halo-2,3'-O-cyclocytidines

Details 5-halo-2,3'-O-cyclocytidines 5-halo-2,3'-O-cyclocytidines

1994-02-02

1996-06-18

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 2852, A61K 3170, C07H 1909

Patent

active

055277829

ABSTRACT:
A 5'-halo-2,3'-O-cyclocytidine of Formula I: ##STR1## wherein: X is a bromide, chloride, or iodide;
Y is halide, sulfate, acetate, tosyl, mesyl, benzoate, and phosphate;
R.sup.1 is hydrogen; and
R.sup.2 is a hydroxy protecting group.
Pharmaceutical compositions containing the above compounds exhibit antineoplastic activity.

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