5-Guanidino-1,2,4-oxadiazoles

Details 5-Guanidino-1,2,4-oxadiazoles 5-Guanidino-1,2,4-oxadiazoles

1980-08-01

1982-07-06

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D27106

Patent

active

043384471

ABSTRACT:
The invention relates to oxadiazole derivatives which are histamine H-2 antagonists and which inhibit the secretion of gastric acid, to methods for their manufacture and to pharmaceutical compositions containing them. The oxadiazole derivatives are of the formula: ##STR1## in which Y is O, S, CH.sub.2 or a direct bond; m is 0 to 4 and n is 1 to 4, provided that when Y is S or O m is 1 to 4 and when Y is O n is 2 to 4; A is a 3,4-dioxocyclobuten-1,2-diyl radical or C.dbd.Z in which Z is O, S, NCN, NNO.sub.2, CHNO.sub.2, NCONH.sub.2, C(CN).sub.2, NCOR.sup.1, NCO.sub.2 R.sup.1, NSO.sub.2 R.sup.1 or NR.sup.2 in which R.sup.1 is alkyl or aryl and R.sup.2 is H or alkyl; B is alkoxy or alkylthio or NHR.sup.3 in which R.sup.3 is H or alkyl: and the salts thereof.

REFERENCES:
Yurugi, et al. "Chem. Pharm. Bull." vol. 21, No. 8, (1973) pp. 1641-1650.

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