5-fluorouracil derivatives useful as carcinostatic substances

Details 5-fluorouracil derivatives useful as carcinostatic substances 5-fluorouracil derivatives useful as carcinostatic substances

1987-10-09

1989-03-07

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544313, C07D23954

Patent

active

048107905

ABSTRACT:
A novel 5-fluorouracil derivative of the formula: ##STR1## wherein R.sup.1 is a fluorine-containing C.sub.1 -C.sub.10 organic group which optionally contains sulfur, oxygen and/or nitrogen. The novel 5-fluorouracil derivative is useful as a carcinostatic substance, which has a high carcinostatic activity but which is less toxicity against digestive tract and causes less autonomic imbalance than other known 5-fluorouracil derivatives.

REFERENCES:
Gan to Kagakmyouhow, 8, No. 11(1981) pp. 1811-1820.
Ishikawa et al., CA85-192754y (1976), "1-carbamoyl-5-fluorouracils".
Ozaki et al., CA88-37728q (1978) "5-F-uracil derivatives, I. The Synthesis of 1-carbanroyl-5-fluorouracils".
Tokyo Kinzoku Kogyo Co. Ltd. CA95-150701e (1981) "Pyrinidine Derivatives".

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