5-Fluorouracil derivatives, and their pharmaceutical composition

Details 5-Fluorouracil derivatives, and their pharmaceutical composition 5-Fluorouracil derivatives, and their pharmaceutical composition

1980-01-14

1982-09-14

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544313, 544311, C07D23930

Patent

active

043495524

ABSTRACT:
A compound of the formula: ##STR1## wherein R is a bridged alicyclic group selected from the group consisting of norbornyl, norbornenyl, bicyclo[2,2,2]-heptyl and adamantyl optionally substituted by at least one substituent selected from the group consisting of lower alkyl, carboxy, lower alkoxycarbonyl, alkylidenedioxy, N,N-di(lower)alkylcarbamoyl, amino, loweralkoxycarbonylamino and halogen. The present compound is useful in the therapeutic treatment of cancer in human beings and animals.

REFERENCES:
patent: 3971784 (1976-07-01), Tada
patent: 4032524 (1977-06-01), Ozaki et al.
patent: 4071519 (1978-01-01), Ozaki
patent: 4088646 (1972-05-01), Ishida et al.
CA vol. 88, No. 3, p. 644 22966p (1972).

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