5-Fluorouracil derivatives

Details 5-Fluorouracil derivatives 5-Fluorouracil derivatives

1976-03-11

1978-09-12

Coughlan, Jr., Paul M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D23922

Patent

active

041139496

ABSTRACT:
Direct fluorination of uracil and its derivatives, in the presence of an aqueous solvent, by fluorine gas to produce 5-fluorouracil and 5-fluorouracil derivatives is disclosed. Novel compounds produced by the reaction, such as 5,5-difluoro-6-hydroxy-5,6-dihydrouracil are also disclosed. The derivatives of 5-fluorouracil are useful as germicidal agents while 5-fluorouracil itself is a known cancer chemotherapy agent.

REFERENCES:
patent: 3277092 (1966-10-01), Duschinsky et al.
patent: 3360523 (1967-12-01), Loux
patent: 3669970 (1972-06-01), Lutz et al.

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