5-fluorouracil derivatives

Details 5-fluorouracil derivatives 5-fluorouracil derivatives

1988-07-15

1991-01-08

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544310, 536 23, A61K 31505, C07D23910

Patent

active

049836099

ABSTRACT:
An anticancer compound is disclosed which is represented by the formula ##STR1## wherein one of R.sup.1 and R.sup.2 is a phenyl-lower alkyl optionally having a substituent, phenyl-lower alkenyl or naphthyl-lower alkyl, the other of R.sup.1 and R.sup.2 is hydrogen or acyl, and R.sup.3 is hydrogen, acyl or tetrahydrofuranyl, or represented by the formula ##STR2## wherein R.sup.x is an optionally substituted pyridyl, Y is arylene and .alpha. is a known 5-fluorouracil derivative residue which can be converted to 5-fluorouracil in vivo and which is linked to the carbonyl by an ester or amide linkage.

REFERENCES:
patent: 4124765 (1978-11-01), Kurona
patent: 4425335 (1984-01-01), Fujii
patent: 4472386 (1984-09-01), Kodama et al.
patent: 4528372 (1985-07-01), Kigasawa et al.
patent: 4605738 (1986-08-01), Kamata et al.
patent: 4613604 (1986-09-01), Chu
patent: 4705791 (1987-10-01), Benneche
patent: 4778797 (1988-10-01), Toyoshima et al.
patent: 4864021 (1989-09-01), Fujii
patent: 4868189 (1989-09-01), Korono et al.
patent: 4914105 (1990-04-01), Fujii et al.
Chem. Abstr., vol. 105 Entry 97331f(1986)(Fujii) Abstracting EP 180188.
Chem. Abstr. vol. 101 Entry 55487y(1984).
Chem. Abstr., vol. 105 Entry 97878g(1986).
Chem. Abstr., vol. 107 Entry 1068368c(1987).
Chem. Abstr., vol. 108 Entry 186765e(1988).
Chem. Abstr., vol. 110 Entry 205188d(1989).
Chem. Abstr. vol. 109 Entry 6904p(1988) Abstracting PCT.

Affiliated with

Also associated with

Rating

5-fluorouracil derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-fluorouracil derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-fluorouracil derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-935030