5-fluoro-3-oxa-prostacyclin compounds

Details 5-fluoro-3-oxa-prostacyclin compounds 5-fluoro-3-oxa-prostacyclin compounds

1985-09-18

1987-08-18

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549 9, 549 13, 549 60, 549 88, 549214, 549346, 549510, 549511, 549465, C07D30906, C07D307935

Patent

active

046878645

ABSTRACT:
The present invention describes 5-fluoro-3-oxaprostacyclin (PGI.sub.2) derivatives of Formula I. These compounds are useful for the treatment of platelet dysfunction, atherosclerosis, hypertension and tumor cell metastasis. Also disclosed is the process for preparing them and the appropriate intermediates. ##STR1## wherein R.sup.1 is: (a) Na, K, or 1/2 Ca, or other pharmaceutically acceptable cation

REFERENCES:
patent: 4324730 (1982-04-01), Fried

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