5-fluoro-3-oxa-6,7-didehydro-PGI.sub.1 compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...


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549 13, 549 60, 549214, 549414, C07D307935




The present invention describes 5-fluoro-3-oxa-prostacyclin (PGI.sub.2) derivatives of Formula I. These compounds are useful for the treatment of platelet dysfunction, atherosclerosis, hypertension and tumor cell metastasis. Also disclosed is the process for preparing them and the appropriate intermediates. ##STR1## wherein R.sup.1 is: (a) Na, K, or 1/2 Ca, or other pharmaceutically acceptable cation

patent: 4324730 (1982-04-01), Fried
Mitra, The Synthesis of Prostaglandins, Wiley (1977), pp. 236-237, 318-319 and 386-387.


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