5-fluoro-3,4-dihydro-2,4-dioxo-N-(3-indolyl)-1(2H)-pyrimidinecar

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

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544311, C07D40302

Patent

active

047926074

ABSTRACT:
5-Fluorouracil derivatives of this invention are represented by the general formula: ##STR1## wherein R indicates an alkylene group having 1-8 carbon atoms, A indicates an atomic group of --NH-- and --CO--, n is 0 or 1, and Y indicates an alkyl group having 1-10 carbon atoms, an aryl group, a heteroaryl group, a pyridinium ion having a halogen as a pair ion or an isocyanate group.
These derivatives are useful as anticancer medicines and intermediates therefor.
These derivatives are produced by six specified methods of this invention. A representative method is a process which comprises reacting 5-fluorouracil and an isocyanate represented by a general formula:

REFERENCES:
patent: 4349552 (1982-09-01), Takaya et al.
Ozaki et al., CA 90-54966w.
Tokyo Metal Industries, CA 95-25106p.
Ozaki et al., CA 106-66979q.

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