5'-diphosphohexose nucleoside pharmaceutical compositions

Details 5'-diphosphohexose nucleoside pharmaceutical compositions 5'-diphosphohexose nucleoside pharmaceutical compositions

1990-07-11

1992-06-02

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 48, 514 51, 514 438, 514441, 514445, 514461, 514463, 514473, A61K 3170, A61K 31385, A61K 3138, A61K 4308

Patent

active

051186721

ABSTRACT:
This invention provides compounds and pharmaceutical compositions that include compounds of the formula: ##STR1## in which A, B, and C are hydrogen, halogen, or azido; D is hydrogen, halogen, azido, or OH; A and B or C and D can be replaced with a double bond; R is an aldohexose, aldohexosamine, or N-acetyl aldohexosamine, W is O or S; X is O, S, or CH.sub.2 ; Y is a purine or pyrimidine base, Z is C, S, or O, and wherein when Z is S or O, A and C are not present. The compounds of this inverntion have enhanced pharmaceutical or biological activity or increased intracellular absorption compared to the corresponding parent nucleoside as a function of the 5'-diphosphohexose moiety. Many of these compounds have antiviral, including anti-HIV, activity. Others have antibacterial activity. In one embodiment, the invention is a method to treat HIV infection and opportunistic infections concomitantly.

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