5-dialkylaminomethyl-2-furanomethanol derivatives having anti-hy

Details 5-dialkylaminomethyl-2-furanomethanol derivatives having anti-hy 5-dialkylaminomethyl-2-furanomethanol derivatives having anti-hy

1989-05-12

1991-05-21

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514336, 514343, 546194, 546281, 546283, 544 55, 544 585, 544 63, 544 96, 544124, 544360, C07D40113, C07D40512, C07D40514, A61K 31435

Patent

active

050175866

ABSTRACT:
Derivatives of 5-aminomethyl-2-furanomethanol represented by formula (I), or pharmaceutically acceptable salts thereof, which possess calcium-antagonistic activity and are effective in lowering blood pressure, and a process for preparing and using the same: ##STR1## wherein R, R.sub.1, R.sub.2 and R.sub.2 ' each represent a lower alkyl group containing 1 to 4 carbon atoms, with the proviso that R.sub.2 and R.sub.2 ', together with N, may form a 5- or 6-membered saturated heterocyclic ring which may contain an additional heteroatom, selected from the group consisting of as O, N and S, or R.sub.2 ' represents an aralkyl group;
wherein R.sub.3 and R.sub.4 are each selected from the group consisting of a hydrogen atom, a halogen, a nitro group and a methoxy group; and
wherein R.sub.5 is selected from the group consisting of a halogen, a difluoromethoxy group, a trifluoromethyl group, a nitro group, a carbamylmethoxy group, a cyanomethoxy group and a mesyloxy group.

REFERENCES:
Chemical Abstracts; 70:875080f; 1969.
Chemical Abstracts; 84:17090m; 1976.
Chemical Abstracts; 98:215490u; 1983.
Chemical Abstracts; 101:110746j; 1984.
Chemical Abstracts; 101:151862n; 1984.

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