5'deoxy-5'-substituted adenosines

Details 5'deoxy-5'-substituted adenosines 5'deoxy-5'-substituted adenosines

1987-02-10

1988-12-27

Brown, J. R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 23, 536 24, 536 27, 514 43, 514 45, 514 46, C07H 1916, C12P 1928

Patent

active

047941740

ABSTRACT:
In accordance with this invention, there are provided 5'-deoxy-5'-substituted adenosines having the formula ##STR1## wherein X is a member selected from the group consisting of NH, NCH.sub.3, S, or ##STR2## n is an integer from 2-4; and Z is a member selected from the group consisting of: ##STR3## provided that when X is NH, S or CH.sub.3 --S .sym., then Z is not ONH.sub.2. These compounds show activity as inhibitors of AdoMet-DC.

REFERENCES:
patent: 3954726 (1976-05-01), Fiecchi
patent: 4242505 (1980-12-01), Kawahara
patent: 4621056 (1986-11-01), Gennari
Khomutou et al. (II), Bioorg. Khim., vol. 12 (12), pp. 1662-1674 (1986).
Kolb et al., Liebigs Ann. Chem., (1985), pp. 1036-1040.

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