5'-Deoxy-5-fluorouridine

Details 5'-Deoxy-5-fluorouridine 5'-Deoxy-5-fluorouridine

1980-06-05

1982-07-20

Hazel, Blondel

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 41, 536 182, C07H 1906

Patent

active

043407293

ABSTRACT:
A process for the manufacture of 5'-deoxy-5-fluorouridine which is a potent antitumor agent. The process comprises cleaving the acyl groups from a 1-(5-deoxy-2,3-di-O-acyl-.beta.-D-ribofuranosyl)-5-fluorouracil, a novel intermediate in the process.

REFERENCES:
patent: 4071680 (1978-01-01), Cook
patent: 4122251 (1978-10-01), Misaki et al.
Chemical Abstract 77, 126977g (1972).
Angew, Chemie, Int. Ed. 14, 421 (1975).
J. Med. Chem., 11, 148-151 (1968).
J. Heterocycl. Chem. 9, 445-446 (1972).
Nucleic Acids Res. 3, 1125-37 (1976).

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