5-Deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, methods f

Details 5-Deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, methods f 5-Deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, methods f

1976-06-30

1977-10-11

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated via claimed linking group, bond, chelating agent,...

195 96, 195 31R, 536 10, 536 17, A61K 3171, C07H 1522

Patent

active

040535916

ABSTRACT:
5-Deoxy-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitols, useful antibacterial agents, are prepared by the reaction of the corresponding 5-O-thioformyl-4,6-di-O-(aminoglycosyl)-1,3-diaminocyclitol having all amino functions and all primary and secondary hydroxyl groups protected, with an organotin hydride (preferably tri-n-butylstannane) in an inert aprotic solvent under an inert atmosphere at temperatures of at least about 100.degree. C, followed by removal of said hydroxyl and amino protecting groups.

REFERENCES:
patent: 3828021 (1974-08-01), Beattie et al.
patent: 3868360 (1975-02-01), Daniels et al.
patent: 3920628 (1975-11-01), Daniels et al.
patent: 3972930 (1976-08-01), Daum et al.
patent: 3982996 (1976-09-01), Daum et al.
patent: 4003922 (1977-01-01), Kavadias et al.
Perkins, "J. Chem. Soc.", No. 16, pp. 1574-1585, 1975.

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