5-Cyano-prostacyclin derivatives

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424274, 424275, 424283, 424285, 542426, 542429, 542430, 546269, 549 60, 26032636, 2603457P, 2603458P, 26034622, 26034673, A61K 31335, C07D30793

Patent

active

042194792

ABSTRACT:
Stabilized prostacyclins having a wide range of pharmacological activity and long duration of such activity, have the formula ##STR1## wherein R.sub.1 is (a) OR.sub.3, wherein R.sub.3 is hydrogen, alkyl, cycloalkyl, aryl or a heterocyclic residue; or (b) NHR.sub.4 wherein R.sub.4 is an acid residue;

REFERENCES:
Vorbruggen, Tetrahedron Letters, 1968, pp. 1631-1633.

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