5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful in the treatme

Details 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful in the treatme 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful in the treatme

1992-02-06

1993-08-17

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3141

Patent

active

052369420

ABSTRACT:
This invention relates to the enhancement of memory and cognition and the treatment of Alzheimer's disease by administration of 5-(R.sub.n -phenyl)-4-alkyl-3H-1,2,4-triazole-3-thiones of the formula ##STR1## wherein R is halogen, trifluoromethyl, C.sub.1-4 lower alkyl or C.sub.1-4 lower alkoxy,

REFERENCES:
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patent: 4912095 (1990-03-01), Kane et al.
G. Maffi, et al., Il. Farmaco. Ed. Sci., 629-38 (1958) (Translation provided).
J. P. Henichart, et al. Mol. Pharmacol., 20(3), 598-601 (1981).
J. P. Henichart, et al Eur. J. Med. Chem.-Chim. Ther., 12(2), 117-2 (1977).
K. C. Joshi, et al. J. Indian Chem. Soc., 51(6), 613-5 (1974).
J. M. Kane, Synthesis (10), 912-9 (1987).
J. M. Kane, M. W. Dudley, S. M. Sorenson, and F. P. Miller, J. Med. Chem. 31(6), 1253-8 (1988).

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