5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enha

Details 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enha 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enha

1991-02-26

1992-03-31

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A01N 4364

Patent

active

051009064

ABSTRACT:
This invention relates to the enhancement of memory and cognition and the treatment of Alzheimer's disease and Wernicke-Korsakoff syndrome by administration of 5-(R.sub.n -phenyl)-4-alkyl-3H-1,2,4-triazole-3-thiones of the formula ##STR1## wherein R is halogen, trifluoromethyl, C.sub.1-4 lower alkyl or

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J. M. Kane, Synthesis (10), 912-9 (1987).
J. M. Kane, M. W. Dudley, S. M. Sorenson, and F. P. Miller, J. Med. Chem. 31(6), 1253-8 (1988).

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