Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-08-11
1994-07-19
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3128
Patent
active
053310020
ABSTRACT:
This invention relates to the enhancement of memory and cognition and the treatment of Alzheimer's disease and Wernicke-Korsakoff syndrome by administration of 5-(R.sub.n -phenyl)-4-alkyl-3H-1,2,4-triazole-3-thiones of the formula ##STR1## wherein R is halogen, trifluoromethyl, C.sub.1-4 lower alkyl or
REFERENCES:
patent: 4732900 (1988-03-01), Weber et al.
patent: 4775688 (1988-10-01), Kane et al.
patent: 4847276 (1989-07-01), Yarrington
patent: 4912095 (1990-03-01), Kane et al.
G. Maffii, et al., II. Farmaco. Ed. Sci., 13, 629-38 (1958) (Translation provided).
J. P. Henichart, et al. Mol. Pharmacol., 20(3), 598-601 (1981).
J. P. Henichart, et al. Eur. J. Med. Chem.-Chim. Ther., 12(2), 117-2 (1977).
K. C. Joshi, et al. J. Indian Chem. Soc., 51(6), 613-5 (1974).
J. M. Kane. Synthesis (10), 912-4 (1987).
J. M. Kane, M. W. Dudley, S. M. Sorenson, and F. P. Miller, J. Med. Chem. 31(6), 1253-8 (1988).
D. E. Sternberg, et al. Archives of General Psychiatry, vol. 33, No. 2, Feb. 1976 pp. 219-224.
Cintins Marianne M.
Criares T. J.
Merrell Dow Pharmaceuticals Inc.
Simmons Edlyn S.
LandOfFree
5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enha does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enha, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-aryl-4-alkyl-3H-1,2,4-triazole-3-thiones useful as memory enha will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-520290