5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of

Details 5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of 5-aryl-3H-1,2,4-triazol-3-ones and their use in the treatment of

1990-03-15

1995-07-25

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 514340, 514384, 514422, 514444, 514471, 514464, A61K 3147

Patent

active

054362520

ABSTRACT:
This invention relates to neuroprotective 5-aryl-3H-1,2,4-triazol-3-ones and to their use in the treatment of neurodegenerative disorders such as cerebral ischemia, stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease.

REFERENCES:
patent: 3514466 (1970-05-01), Stahle et al.
patent: 4414221 (1983-11-01), Parsons et al.
patent: 4946856 (1990-08-01), Kane et al.
Kane et al "2,4-dihydro-3H-1,2,4-triazole-3-thiones as potential antidepressants agents" CA 108-221674y (1988).
Deliwala et al "Further studies in substituted 4H-1,2,4-triazoles for possible hypoglycemic activity" CA 74-111968u (1971).
Mazzone et al "Cyclic derivatives from alkoxybenzohydrazides. Synthesis of pyrazoles, pyrroles and triazol-5-ones of pharmaceutical interest" CA 106-196338r (1987).
Akerblom et al "Nitrofuryltriazole derivatives as potential urinary tract antibacterial agents" CA 79-87327q (1973).
Kane et al "2,4-dihydro-3H-1,2,4-triazol-3-ones as anticonvulsant agents" CA 113-152341b (1990).
The Merck Manual "Convulsive Seizures (including epilepsy)" pp. 1008-1009 (1966).
G. Maffii, et al., Studio farmacologico di alcuni ossadiazoli e triazoli, Farmaco 13, 629-38 (1958). (Translation provided).
F. P. Miller, et al., FASEB J. 2, A1070, abstract 4501 (1988).

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