Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1981-08-20
1984-02-14
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
548411, 548452, C07D20902, C07D40502, A61K 3140
Patent
active
044316615
ABSTRACT:
Novel compounds are disclosed having the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are each individually selected from the class consisting essentially of hydrogen, hydroxy, chloro, bromo, an alkyl radical having up to 3 carbon atoms, an alkoxy radical having up to 3 carbon atoms, and trifluoromethyl, and any two or more of R.sub.1, R.sub.2 and R.sub.3 may be the same; R.sub.4 is selected from the class consisting essentially of hydrogen, an alkyl radical having up to 3 carbon atoms, an allyl radical having up to 4 carbon atoms, the cyclopropylmethyl radical or the phenethyl radical; and W and W' each represent a monovalent alkyl moiety having up to 3 carbon atoms or W-W' jointly represent a divalent moiety of the formula ##STR2## where n is an integer of 2 or 3, including individual optically active isomers, racemic mixtures thereof, and non-toxic pharmacologically-acceptable acid-addition salts thereof. Such compounds are useful as analgesics in mammals. They can be prepared by irradiating with ultra-violet light a mixture of a dialkoxyethylene and a maleimide of the formula ##STR3## to produce a 4,4-dialkoxy-N-alkyl-1-phenyl-1,2-cyclobutanedicarboximide, and chemically reducing the same. Three other processes of preparation are also described.
REFERENCES:
patent: 4088652 (1978-05-01), Fanshawe et al.
patent: 4118417 (1978-10-01), Epstein
patent: 4131611 (1978-12-01), Fanshawe et al.
Epstein Joseph W.
Fanshawe William J.
McKenzie Thomas C.
American Cyanamid Company
Coughlan, Jr. Paul M.
Springer D. B.
Timbers Mary-Ellen M.
LandOfFree
5-Aryl-3-azabicyclo[3.2.0]heptan-6-one acetals, and analgesic us does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one acetals, and analgesic us, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one acetals, and analgesic us will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2374983