5-anilinoimidazo[1,5-a]-pyridines inhibitors of MEK kinase

Details 5-anilinoimidazo[1,5-a]-pyridines inhibitors of MEK kinase 5-anilinoimidazo[1,5-a]-pyridines inhibitors of MEK kinase

2011-04-12

2011-04-12

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S121000

Reexamination Certificate

active

07923456

ABSTRACT:
The invention relates to imidazopyridines of formula I with anti-cancer and/or anti-inflammatory activity and more specifically to imidazopyridines which inhibit MEK kinase activity. The invention provides compositions and methods useful for inhibiting abnormal cell growth or treating a hyperproliferative disorder, or treating an inflammatory disease in a mammal. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

REFERENCES:
patent: 2005/0049276 (2005-03-01), Kaufman et al.
patent: 2005/0153942 (2005-07-01), Wallace et al.
patent: WO 02/06213 (2002-01-01), None
patent: WO 03/077855 (2003-09-01), None
patent: WO 03/077914 (2003-09-01), None
Hoshino et al., “Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors”Oncogene18:813-822 (1999).
Lewis et al., “Signal transduction through MAP kinase cascades”Adv Cancer Res.74:49-139 (1998).
Price, B., “Putative allosteric MEK1 and MEK2 inhibitors”Expert Opin.Ther. Patents18(6) :603-627 (2008).
Sebolt-Leopold et al., “Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo”Nature Medicine5(7) :810-816 (Jul. 1999).

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