5- And/or 7-substituted pyrazolo-[4,3-b]-pyridines and their use

Details 5- And/or 7-substituted pyrazolo-[4,3-b]-pyridines and their use 5- And/or 7-substituted pyrazolo-[4,3-b]-pyridines and their use

1984-03-07

1985-12-17

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546119, A61K 31415, C07D47104

Patent

active

045593485

ABSTRACT:
Compounds of the formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: the first of R.sub.1 and R.sub.2 is hydrogen, C.sub.1-4 alkyl or phenyl optionally substituted by one or two substituents selected from halogen, CF.sub.3, C.sub.1-4 alkoxy or alkyl and the second is SR.sub.4 wherein R.sub.4 is phenyl optionally substituted by halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl, or NR.sub.5 R.sub.6 wherein R.sub.5 and R.sub.6 are independently selected from hydrogen, C.sub.1-6 alkyl, C.sub.3-8 cycloalkyl, phenyl or phenyl C.sub.1-4 alkyl either of which phenyl moieties may be substituted by one or two substituents selected from halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl, or R.sub.5 and R.sub.6 together form C.sub.4-6 polymethylene; and

REFERENCES:
Foster, H. E. and Hurst, J., J. Chem. Soc. Perkin I, 2901-07, (1973), and 507-12, (1976).
Ajello, E., Journal of Heterocyclic Chemistry, vol. 8, 1035-37, (1971).
Hylton Foster and Jim Hurst, J. Chem. Soc. Perkin Trans. I, 1976(5), 507-512.

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