5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-b

Details 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-b 5- and 6-(2-imidazolin-2-ylamino) and -(2-thiazolin-2-ylamino)-b

1996-02-29

1997-10-14

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514367, 514397, 548161, 548178, 548181, 548183, 548190, 548234, 5483121, A61K 31425, A61K 31415, C07D27782, C07D27762, C07D40302

Patent

active

056773218

ABSTRACT:
This invention is directed to indole and benzothiazole compounds which are selective for cloned human alpha 2 receptors. This invention is also related to uses of these compounds for any indication where use of an alpha 2 agonist may be appropriate. Specifically, this includes use as analgesic, sedative and anaesthetic agents. In addition, this invention includes using such compounds for lowering intraocular pressure, presbyopia, treating migraine, hypertension, alcohol withdrawal, drug addiction, rheumatoid arthritis, ischemic pain, spasticity, diarrhea, nasal decongestion, urinary incontinence as well as for use as cognition enhancers and ocular vasoconstriction agents. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

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