5-aminosalicylic acid-O-sulfates of physiologically acceptable b

Details 5-aminosalicylic acid-O-sulfates of physiologically acceptable b 5-aminosalicylic acid-O-sulfates of physiologically acceptable b

1988-07-25

1989-06-06

Siegel, Alan

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

558 37, A61K 3138, C07C 7100

Patent

active

048372293

ABSTRACT:
5-Aminosalicylic acid O-sulfates of physiologically acceptable bases are new substances which are preparable by esterification of 5-nitrosalicylic acid alkyl esters with carbodiimide and sulfuric acid, alkaline saponification of the alkyl ester group and reduction of the thus obtained 5-nitrosalicylic acid O-sulfates. Said substances are useful as drugs, more specifically for the treatment of colitis ulcerosa, enteritis regionalis Crohn (morbus Crohn), chronic nonspecific colitis and diverticulitis.

REFERENCES:
Chemical Abstracts Index 79 53744 (1973).
Engel, J. Amer. Chem. Soc., 51, 3483 (1929).

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