5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid d

Details 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid d 5-Aminomethyl-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid d

1981-05-04

1983-02-01

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544139, 546210, 546278, 548321, C07D24104, C07D23304

Patent

active

043717373

ABSTRACT:
2,3-Dihydro-2-oxo-1H-imidazole-4-carboxylic acid derivatives having a (substituted amino)methyl substituent at the 5-position, are useful as cardiotonics, antihypertensives and antithrombotic agents. The compounds are obtained by the reaction of an appropriate amine with a 5-(bromomethyl)-2,3-dihydro-2-oxo-1H-imidazole-4-carboxylic acid ester or amide.

REFERENCES:
patent: 2441933 (1945-07-01), Duschinsky
patent: 2514380 (1926-12-01), Duschinsky
patent: 3303199 (1967-02-01), Doebel et al.
patent: 3895934 (1975-07-01), Linder et al.
Boularand et al., Chimie Ther., 8, 638 (1973).
Duschinsky et al., J. Am. Chem. Soc., 68, 2350 (1946).
Duschinsky et al., J. Am. Chem. Soc., 70, 657 (1948).
Dage et al., Fed. Proc., 39, 1105 (1980) (abstract).

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