Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-01-17
2008-11-25
Dentz, Bernard (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S130000
Reexamination Certificate
active
07456174
ABSTRACT:
The present invention relates to compounds of formula Iwherein R1, R2, R3, R4and m are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
REFERENCES:
patent: 5756507 (1998-05-01), Goulet et al.
patent: 2003/0069278 (2003-04-01), Zhou et al.
patent: WO 01/74773 (2001-10-01), None
patent: WO 01/74814 (2001-10-01), None
patent: WO 04/000831 (2003-12-01), None
patent: WO 2005/123716 (2005-12-01), None
Yoshimoto et. al., Proc. Natl. Acad. Sci. USA, Sep. 12, 2006, 103(37), 13866-71.
Nagai et al., Exp. Biol. Med. (Maywood), Nov. 2003, 228(10) 1138-45.
Hancock, et al, Expert Opinion Investig. Drugs, Oct. 2004, 13(10), 1237-48.
Lehmann et al., Drugs, 2003, 63(17), 1785-97.
Burks 1994 in Johnson L.R. ed., Physiology of the Gastrointestinal Tract, Raven Press, NY, pp. 211-242.
Leurs et al., Br J. Pharmacol. 1991, 102, pp. 179-185.
Raithel et al., Int. Arch. Allergy Immunol. 1995, 108, 127-133.
Panula et al., Proc. Natl. Acad. Sci. USA 1984, 81, 2572-2576.
Inagaki et al., J. Comp. Neurol 1988, 273, 283-300.
Arrang et al., Nature 1983, 302, 832-837.
Arrang et al., Neuroscience 1987, 23, 149-157.
Clapham & Kilpatrik, Br. J. Pharmacol. 1982, 107, 919-923.
Blandina et al. in The Histamine H3 Receptor (Leurs RL and Timmermann H eds, 1998, pp. 27-40, Elsevier, Amsterdam, The Netherlands.
Masaki et al; Endocrinol. 2003, 144, 2741-2748.
Hancock et al., European J. of Pharmacol. 2004, 487, 183-197.
Timmermann, J. Med. Chem. 1990, 33, 4-11.
Nettekoven Matthias Heinrich
Plancher Jean-Marc
Roche Olivier
Rodriguez-Sarmiento Rosa Maria
Dentz Bernard
Gallis David E
Hoffmann-La Roche Inc.
Johnston George W.
Megerditchian Samuel H.
LandOfFree
5-aminoindole derivatives as H3 inverse agonists does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 5-aminoindole derivatives as H3 inverse agonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-aminoindole derivatives as H3 inverse agonists will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4025227