5-aminoflavone derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

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544376, 546196, 5483114, 548454, 548525, 549403, C07D31130, C07D41312

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active

055391125

ABSTRACT:
5-Aminoflavone derivatives represented by the formula (I): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same or different and represent hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, halogen-substituted or unsubstituted lower alkanoyl or lower alkoxycarbonyl, X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2 are the same or different and represent hydrogen, halogen or lower alkyl, at least one of X.sup.1 and X.sup.2 represents halogen or lower alkyl, X.sup.3 represents hydrogen, substituted or unsubstituted lower alkyl, lower alkenyl, lower alkynyl, halogen, hydroxy, substituted or unsubstituted lower alkoxy, NR.sup.5 R.sup.6 (wherein R.sup.5 and R.sup.6 are the same or different and represent hydrogen, or substituted or unsubstituted lower alkyl, or R.sup.5 and R.sup.6 are taken together to form a heterocyclic group containing the nitrogen atom in the ring), lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, carboxy, lower alkoxycarbonyl, lower alkanoyl, adizo, cyano, substituted or unsubstituted carbamoyl or lower alkylthiothiocarbonyl: or pharmaceutically acceptable salts thereof.

REFERENCES:
Chemical Abstracts, vol. 113 (1990) 171775n.
Chemical Abstracts, vol. 41, 120 (1947) (Abstract of Iyer et al Proc. Ind. Acad. Sci., vol. 23A (1946) 278:82.).
Eiden et al., Arch. Pharm., vol. 322 (1989) 589:92.
Joshi et al., Ind. J. Chem., vol. 1 (1963) 477:9.
Patent Abstracts of Japan, vol. 14, No. 377 (Aug. 1990) (C-748).
Indian Journal of Chemistry, vol. 1, No. 11 (Nov. 1963) 477:79.
Chemical Abstracts, vol. 119, No. 1 (Jul. 1993).
Chemical Abstracts, vol. 115, No. 21 (Nov. 1995) 22831q.

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