5-aminocarbonyl-5H-dibenzo[a.d]cyclohepten-5,10-imines for treat

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514212, 514286, 540362, 540451, 540480, 540597, 546 72, C07D22122, C07D22310, A61K 3144, A61K 3155

Patent

active

051964155

ABSTRACT:
This invention is in the field of clinical neurology and relates specifically to compounds, compositions and methods for treatment of patients with generalized epilepsy or partial (symptomatic) epilepsy using compounds of the formula: ##STR1## This invention also relates to compounds, compositions and methods of treatment for drug craving in patients addicted to cocaine.

REFERENCES:
patent: 3509158 (1970-04-01), Dobson et al.
patent: 3542787 (1970-11-01), Dobson et al.
patent: 3597433 (1971-08-01), Dobson et al.
patent: 3641038 (1972-02-01), Davis et al.
patent: 3716541 (1973-02-01), Dobson et al.
patent: 3717641 (1973-02-01), Kocsis et al.
patent: 3892756 (1975-07-01), Nedelec et al.
patent: 4009273 (1977-02-01), Nedelec et al.
patent: 4052508 (1977-10-01), Anderson etal.
patent: 4064139 (1977-12-01), Anderson et al.
patent: 4232158 (1980-11-01), Shepard et al.
patent: 4252810 (1981-02-01), Anderson et al.
patent: 4374838 (1983-02-01), Anderson et al.
patent: 4399141 (1983-08-01), Anderson et al.
patent: 4414154 (1983-11-01), Anderson et al.
patent: 4870079 (1989-09-01), Britcher et al.
patent: 4940789 (1990-07-01), Childers, Jr. et al.
patent: 4996211 (1991-02-01), Baker et al.
patent: 5011834 (1991-04-01), Weber et al.
Monn et al. J. Med. Chem. 1990, 33 1069-1076.
Monn et al. Tetrahedron Letters 30(8) 911-914 1989.
Clineschmidt et al. Chemical Abstracts, vol. 97 1982, Abstract 16955d.
Rogawaski et al., "Anticonvulsant Activity of the Low-Affinity Uncompetitive N-Methyl--D-aspartate Antagonist (.+-.)-5-Aminocarbonyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine (ADCl): Comparison with the Structural Analogs Dizocilpine (MK-801) and Carbamazepine," J. Pharmacology and Experimental Therapeutics, 259(1), 30-37 (1991).
Rogawski et al., "A Novel Anticonvulsant Structurally Related to the NMDA Antagonist MK-801 and to Carbamazepine," Epilepsia, 31, 620 (1990).
Yamaguchi et al., "Effects of Anticonvulsant Drugs on 4-Aminopyridine-Induced Seizures in Mice," Epilepsy Res., 11, 9-16 (1992).
Coleman et al., "Protection Against Dendrotoxin-Induced Clonic Seizures in Mice by Anticonvulsant Drugs," Brian Research, 575, 138-142 (1992).
Novelli et al., "Glutamate Becomes Neurotoxic Via the N-methyl-D-aspartate Receptor When Intracellular Energy Levels Are Reduced," Brain Research, 45, 205-212 (1988).
Lysko et al., "Excitatory Aminco Acid Neurotoxicity at the N-methyl-D-aspartate Receptor in Cultured Neurons: Pharmacological Characterization," Brain Research, 499, 258-266 (1989).
Grant et al., "Comparison of the Effects of the Uncompetitive N-Methyl-D-Asparatate Antagonist (.+-.)-5-Aminocarbonyl-10,11-Dihydro-5H-Dibenzo[a,d]cyclohepten-5,10-Imine (ADCL) with Its Structural Analogs Dizocilpine (MK-801) and Carbamazepine on Ethanol Withdrawal Seizures," J. Pharmacology and Experimental Therapeutics, 260(3), 1017-1022 (1992).
Rogawski et al., "Antiepileptic Drugs: Pharmacological Mechanisms and Clinical Efficacy with Consideration of Promising Development Stage Compounds," Pharmacological Reviews, 42(3), 223-286 (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

5-aminocarbonyl-5H-dibenzo[a.d]cyclohepten-5,10-imines for treat does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 5-aminocarbonyl-5H-dibenzo[a.d]cyclohepten-5,10-imines for treat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-aminocarbonyl-5H-dibenzo[a.d]cyclohepten-5,10-imines for treat will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1351759

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.