Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-06-17
1996-08-20
Ivy, C. Warren
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546153, C07D215233, A61K 3147
Patent
active
055479626
ABSTRACT:
A 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative represented by the general formula: ##STR1## wherein R.sup.1 is a hydrogen atom or a lower alkyl group; R.sup.2 is a hydrogen atom, a lower alkyl group, a lower alkanoyl group, a halogenated lower alkanoyl group or a residue of carboxylic acid ester; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4, R.sup.5 or R.sup.6 are each independently a hydrogen atom or a lower alkyl group; or two of R.sup.4, R.sup.5 and R.sup.6 may be taken together to form a --(CH.sub.2).sub.n -group wherein n is 1 or 2, a stereoisomer thereof, or a pharmacologically acceptable salt thereof, the process for preparing these compounds, a pharmaceutical composition comprising an effective amount of these compounds and methods for the treatment of infectious diseases through the administration to patients of an effective amount of these compounds, and intermediates of these compounds are disclosed. These compounds are effective as antibacterial agents.
REFERENCES:
patent: 4665079 (1987-05-01), Culbertson et al.
patent: 4753953 (1988-06-01), Masuzawa et al.
patent: 4771055 (1988-09-01), Domagala et al.
patent: 4791118 (1988-12-01), Masuzawa
patent: 4886810 (1989-12-01), Matsumoto et al.
patent: 4894458 (1990-01-01), Masuzawa et al.
patent: 4971967 (1990-11-01), Kondo et al.
patent: 4988709 (1991-01-01), Ogata et al.
patent: 4990508 (1991-02-01), Narita et al.
patent: 4990517 (1991-02-01), Petersen et al.
patent: 5013841 (1991-05-01), Matsumoto et al.
patent: 5043450 (1991-08-01), Masuzawa et al.
patent: 5045549 (1991-09-01), Sauter et al.
patent: 5051418 (1991-09-01), Schriewer et al.
patent: 5137892 (1992-08-01), Chu
patent: 5145853 (1992-09-01), Metzger et al.
patent: 5153203 (1992-10-01), Yatsunami et al.
patent: 5164392 (1992-11-01), Matsumoto et al.
patent: 5173484 (1992-12-01), Petersen et al.
patent: 5190955 (1993-03-01), Schriewer et al.
patent: 5202337 (1993-04-01), Petersen et al.
patent: 5245037 (1993-09-01), Kuramoto et al.
patent: 5284842 (1994-02-01), Petersen et al.
patent: 5286723 (1994-02-01), Hayakawa
Araki, "Quinolone Antimicrobial Agents Substituted with Morpholines at the 7-Position. Syntheses and Structure--Activity Relationships", J. Med. Chem., 36: 1356-1363 (1993).
Domagala, "Quinolone Antibacterials Containing the New 7-[3-(1-Amino-ethyl)-1-pyrrolidinyl] Side Chain: The Effects of the 1-Aminoethyl Moiety And Its Stereochemical Configurations on Potency and in Vivo Efficacy", J. Med. Chem., 36: 871-882 (1993).
Hagen, "Synthesis and Antibacterial Activity of New Quinolones Containing a 7-[3-(1-Amino-1-methylethyl)-1-pyrrolidinyl] Moiety. Gram-Positive Agents with Excellent Oral Activity and Low Side-Effect Potential", J. Med. Chem., 37, 733-738 (1994).
Wentland, "Novel Amino-Substituted 3-Quinolinecaboxylic Acid Anti-bacterial Agents: Synthesis and Structure--Activity Relationships", J. Med. Chem., 27: 1103-1108 (1984).
Ito Yasuo
Kado Noriyuki
Kato Hideo
Yamamoto Yo-ichi
Yasuda Singo
Horuriku Seiyaku Co., Ltd.
Ivy C. Warren
M. Mach D. Margaret
LandOfFree
5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid deriv does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid deriv, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid deriv will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2330959