Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Reexamination Certificate
2006-09-14
2011-12-06
Padmanabhan, Sreeni (Department: 1627)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
C514S336000, C514S613000, C514S242000, C514S247000, C514S183000, C514S381000, C514S676000, C514S300000, C548S250000, C548S255000, C548S300100, C564S123000
Reexamination Certificate
active
08071651
ABSTRACT:
Compounds of the general formula (I) or its salt or a compound in which one or more atoms are replaced by their stable, nonradio-active isotopes, in particular its pharmaceutically acceptable salt; in which X is —CH2—; R is a mono- to tetra-substituted, mono- or bicyclic, unsaturated heterocyclic radical having 1 to 4 nitrogen atoms, R2is C1-6alkyl or C3-6cycloalkyl; R3is independently of one another H, C1-6alkyl, C1-6alkoxycarbonyl or C1-6alkanoyl; R4is C2-6alkenyl, C1-6alkyl, unsubstituted or substituted aryl-C1-6alkyl or C3-8cycloalkyl; R5is -Lm-R6; L is C1-6alkylene which is optionally substituted by 1-4 halogen, or a linker: formula (II) n=0, 1 or 2; m=0 or 1; R6is a radical composed of 2 cyclic systems selected from bicyclo[x.y.z]alkyl, spiro[o.p]alkyl, mono- or bioxabicyclo[x.y.z]alkyl or mono- or bioxaspiro[o.p]alkyl, all of which may be substituted by 1-3 substituents selected from C1-6alkyl, C1-6alkoxy, cyano, halogen, C1-6alkoxy-C1-6alkyl, hydroxy-C1-6alkyl or dialkylamino, or if m=0: is also saturated C3-8heterocyclyl which comprises 1-2 oxygen atoms, substituted by 1-3 substituents selected from C1-6alkyl, C1-6alkoxy, cyano, halogen, C1-6alkoxy-C1-6alkyl, hydroxy-C1-6alkyl or dialkylamino, or if m=1: is also saturated C3-8heterocyclyl which comprises 1-2 oxygen atoms, optionally substituted by 1-3 substituents selected from C1-6alkyl, C1-6alkoxy, cyano, halogen, C1-6-alkoxy-C1-6alkyl, hydroxy-C1-6alkyl or dialkylamino; have renin-inhibiting properties and can be used as medicines for the treatment of hypertension.
REFERENCES:
patent: 5559111 (1996-09-01), Göschke et al.
patent: 2008/0280895 (2008-11-01), Herold et al.
patent: 0 678 503 (1995-10-01), None
patent: 2005/090305 (2005-09-01), None
International Search Report issued Feb. 22, 2007 in the International (PCT) Application PCT/EP2006/066369 of which the present application is the U.S. National Stage.
Written Opinion in the International (PCT) Application PCT/EP2006/066369 of which the present application is the U.S. National Stage.
Behnke Dirk
Herold Peter
Jelakovic Stjepan
Mah Robert
Marti Christiane
Carter Kendra D
Novartis AG
Padmanabhan Sreeni
Wenderoth , Lind & Ponack, L.L.P.
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